Jason Schmink, Chemistry, Pd-Catalyzed Aldehyde to Ester Conversion: A Hydrogen Transfer Approach

Posted March 21st, 2013 at 11:37 am.

in Organic Letters, 15. 3, January 15, 2013.

Aliphatic and aromatic aldehydes are successfully converted into their corresponding esters using Pd(OAc)2 and XPhos. This approach utilizes a hydrogen transfer protocol: concomitant reduction of acetone to isopropanol provides an inexpensive and sustainable approach that mitigates the need for other oxidants.

Filed under: chemistry Tags: by Diana Campeggio

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